Hormones can have a wide variety of profound effects on the skin. Estrogen, progesterone and the androgens have for example been shown to regulate the condition of the skin via multiple mechanisms that can address skin degradation, wrinkles and dryness, and stimulate the development of new skin cells. Phytomelatonin has been shown to have very similar effects in laboratory trials. Dr. Ferri's Alpine Plant Melatonin (APM), a patented Phytomelatonin extract, has been used in this serum at 70%. As a result, the Phytomelatonin Rejuvenating Serum has been shown in independent clinical trials to visibly reduce signs of skin aging, while even calming and soothing the skin.